Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats

摘要: Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the underlying mechanisms are not well understood. The present study, utilizing non-obese T2DN diabetic model, demonstrates that myogenic response of middle cerebral artery (MCA) and parenchymal arteriole (PA) autoregulation blood flow (CBF) in surface deep cortex were impaired at both young old ages. CBF was more severe than DM rats, cortex. tone MCA enhanced perfusion pressure range 40-100 mmHg rats but reduced 140-180 rats. No change PA observed whereas it significantly 30-60 Old had blood-brain barrier (BBB) leakage neurodegeneration, vascular density, tight junction, pericyte coverage on capillaries CA3 region hippocampus. Additionally, displayed functional hyperemia spatial learning short- long-term memory non-spatial short-term memory. These results revealed BBB plays an essential role pathogenesis age- diabetes-related dementia. findings will lay foundations discovery anti-diabetic therapies targeting restoring to prevent onset progression dementia elderly DM.