Childhood constipation; an overview of genetic studies and associated syndromes

摘要: Constipation is a common problem in children but little known about its exact pathophysiology. Environmental, behavioural also genetic factors are thought to play role the aetiology of childhood constipation. We provide an overview studies performed Until now, linkage studies, association and direct gene sequencing have failed identify mutations specific genes associated with show that along functional constipation, there numerous clinical syndromes These syndromic forms constipation appear be result affecting all aspects normal physiology human defecation. stress causes should considered evaluation constipated child.