Aging increases the susceptiblity to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia.
作者： Syed Z. Imam , Syed F. Ali
DOI: 10.1046/J.1471-4159.2001.00477.X
关键词:
摘要: Methamphetamine (METH) produces dopaminergic neurotoxicity by the production of reactive oxygen (ROS) and nitrogen (RNS) species. The role free radicals has also been implicated in process aging. present study was designed to evaluate whether METH-induced hyperthermia is a result peroxynitrite if these effects correlate with age. One-, sixand 12-month-old male rats (na 8) were administered single dose METH (0, 5, 10, 20, 40 mg/kg, intraperitoneally). formation 3-nitrotyrosine (3-NT) as marker well dopamine its metabolites DOPAC HVA measured striatum 4-h after METH-administration. Rectal temperature monitored every 30 min administration until 4 h. At mg/kg METH, 100% mortality animals observed, whereas no deaths occurred 1- or 6-monthold rats. An age-dependent increase observed A similar pattern dose-dependent 3-NT depletion age striatum. Furthermore, effect at 5 1-month-old animals, significant 6- animals. These data suggest that aging increases susceptibility toward generation striatal
sci-hub.se 参考文章(32)
Pauling Chu, Kuo Cheng Lan, Fu Chiu Yu, Cluen Sheng Lin, Yuh Feng Lin, Clinical manifestations and prognostic features of acute methamphetamine intoxication Journal of the Formosan Medical Association. ,vol. 97, pp. 528- 533 ,(1998)
William Slikker, Syed F. Ali, Syed Z. Imam, Glenn D. Newport, Yossef Itzhak, Jean L. Cadet, Fakhrul Islam, Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase. Journal of Neurochemistry. ,vol. 76, pp. 745- 749 ,(2008) , 10.1046/J.1471-4159.2001.00029.X
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Syed F. Ali, Paul Haung, Yossef Itzhak, Role of peroxynitrite in methamphetamine-induced dopaminergic neurotoxicity and sensitization in mice. Addiction Biology. ,vol. 5, pp. 331- 341 ,(2000) , 10.1111/J.1369-1600.2000.TB00200.X
Fernando Cardozo-Pelaez, Shijie Song, Anand Parthasarathy, Christopher Hazzi, Kamatham Naidu, Juan Sanchez-Ramos, Oxidative DNA damage in the aging mouse brain Movement Disorders. ,vol. 14, pp. 972- 980 ,(1999) , 10.1002/1531-8257(199911)14:6<972::AID-MDS1010>3.0.CO;2-0
Frederick J. Kogan, William K. Nichols, James W. Gibb, Influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels. European Journal of Pharmacology. ,vol. 36, pp. 363- 371 ,(1976) , 10.1016/0014-2999(76)90090-X
DIANE B. MILLER, JAMES P. O'CALLAGHAN, SYED F. ALI, Age as a susceptibility factor in the striatal dopaminergic neurotoxicity observed in the mouse following substituted amphetamine exposure. Annals of the New York Academy of Sciences. ,vol. 914, pp. 194- 207 ,(2000) , 10.1111/J.1749-6632.2000.TB05196.X
Lewis S Seiden, Marian W Fischman, Charles R Schuster, Long-term methamphetamine induced changes in brain catecholamines in tolerant rhesus monkeys Drug and Alcohol Dependence. ,vol. 1, pp. 215- 219 ,(1976) , 10.1016/0376-8716(76)90030-2
S.Y. Ma, B.J. Ciliax, G. Stebbins, S. Jaffar, J.N. Joyce, E.J. Cochran, J.H. Kordower, D.C. Mash, A.I. Levey, E.J. Mufson, Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra. The Journal of Comparative Neurology. ,vol. 409, pp. 25- 37 ,(1999) , 10.1002/(SICI)1096-9861(19990621)409:1<25::AID-CNE3>3.0.CO;2-E
Walter Adriani, Giovanni Laviola, A unique hormonal and behavioral hyporesponsivity to both forced novelty and d-amphetamine in periadolescent mice Neuropharmacology. ,vol. 39, pp. 334- 346 ,(2000) , 10.1016/S0028-3908(99)00115-X