Effects of bromowillardiine and willardiine on non-N-methyl-D-aspartate receptors in postnatal rat hippocampal neurons.

摘要: The physiology and pharmacology of willardiine bromowillardiine, structural analogues quisqualate, were studied in cultured postnatal rat hippocampal neurons using whole-cell voltage-clamp techniques. These agonists appear to act at a shared non-N-methyl-D-aspartate (non-NMDA) receptor-channel complex gate nonselective cationic currents. Willardiine currents desensitize rapidly much greater degree than bromowillardiine In addition, the brominated compound produces steady state that are 5 times larger those produced by saturation. Bromowillardiine is also more efficacious excitotoxin, producing about 3-fold acute neuronal damage saturating concentrations. results suggest agonist structure affects ability non-NMDA induce desensitization add support hypothesis receptor serves limit excitotoxicity neurons.