Thyroid Hormone Antagonism
作者： J. W. Barlow , T. C. Crowe , D. J. Topliss
DOI: 10.1007/978-3-642-60709-7_13
关键词:
摘要: The development of hormone antagonists, or compounds which can reverse the physiological effects hypersecretion, has been a desirable and achievable goal for many small molecular weight hormones. spectacular successes achieved with antagonists such as spironolactone, RU-486 cimetidine have stimulated pharmacologists pharmaceutical companies to use similar strategies in search an antagonist thyroid hormone. For most part steroid followed classical chemical synthetic route; systematic modifications either ring structure side chains were carried out, new tested bioassay ultimately leading clinical trials, subsequently effective applied practice. Consequently, there is now range are safely able inhibit actions mineralocorticoids, glucocorticoids, androgens progestagens extensive utility. These also remarkably useful tools be used understand mechanisms action laboratory.
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