Emergency Presentations of Immune Checkpoint Inhibitor-Related Endocrinopathies.

摘要: Abstract Background Immune checkpoint inhibitors (ICI) are an important component of anticancer treatment, with indications across increasing range oncological diagnoses. ICIs associated a immune-mediated toxicities. Immune-related endocrinopathies pose distinct challenge, given the nonspecific symptom profile and potentially life-threatening sequelae if not recognized. Objectives To determine frequency clinical presentations in patients treated presenting as emergencies. Methods A prospective observational cohort study was undertaken at specialist oncology hospital North West England from May 20, 2018 to 19, 2020. Within hospital, Oncology Assessment Unit (OAU) acts receiving unit which assessments all emergency presentations. All OAU were included. The primary outcome diagnosis endocrinopathy. Length inpatient stay, 7- 30-day mortality rates examined. Results During period, 684 presented OAU. Twenty-four (3.5%) had acute endocrinopathy, 17 hypophysitis, 4 diabetes mellitus, 2 thyrotoxicosis, 1 adrenalitis. Median length stay for hypophysitis 1 day. No patient endocrinopathy died within 30 days presentation. Conclusions Presentations settings rare. Early recognition toxicities is important, particularly pertinent ICI-related endocrinopathies, where even cases, presentation can be vague nonspecific.