Evidence for the presence of P2y and P2x receptors with different functions in mouse stomach.

摘要: Abstract To clarify the function of P2 receptor subtypes in mouse stomach, motor responses to ATP, α,β-methyleneATP (α,β-MeATP), P2X agonist, 2-methylthioATP (2-MeSATP), P2Y and effects desensitisation receptors with α,β-MeATP ADPβS were analysed recording endoluminal pressure from whole-organ. ATP-induced relaxation was antagonised by suramin, non-selective antagonist, ADPβS, increased α,β-MeATP. produced biphasic responses: relaxation, reduced P2X- or desensitisation, contraction, almost abolished potentiated desensitisation. 2-MeSATP induced which Tetrodotoxin purines deeply contraction Our results suggest that stomach are present muscular receptors, subserving neuronal presynaptic mediating contraction.