Intravitreal Ziv-Aflibercept for Diabetic Macular Edema: 48-Week Outcomes.
作者： Gabriel Costa de Andrade , João Rafael de Oliveira Dias , André Maia , Michel Eid Farah , Carsten H. Meyer
DOI: 10.3928/23258160-20180329-06
关键词:
摘要: BACKGROUND AND OBJECTIVE To study the safety and efficacy of intravitreal injections ziv-aflibercept (IVI-ZA) (Zaltrap; Sanofi-Aventis Regeneron Pharmaceuticals, Tarrytown, NY) during a period 48 weeks in patients with diabetic macular edema (DME). PATIENTS METHODS Seven consecutive DME were enrolled submitted to 12 IVI-ZA 4-week interval. The parameters included changes full-field electroretinogram (ERG) systemic or ocular complications, mean change from baseline best-corrected visual acuity (BCVA) central retinal thickness (CRT). RESULTS No significant differences found any ERG component after IVI-ZA, no complication was observed. improvement BCVA most first remained until week (P < .05). CRT significantly decreased course weeks. CONCLUSION 48-week results are consistent our previous 24-week findings, supporting as safe, efficient, well-tolerated therapy for DME. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:245-250.].
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