The effect of ascorbic acid on the metabolism of rat calvarial bone cells in vitro
作者： Kurt P. Spindler , David B. Shapiro , Stephen B. Gross , Carl T. Brighton , Charles C. Clark
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摘要: Addition of 50 micrograms/ml sodium ascorbate to confluent cultures isolated rat calvarium bone cells resulted in a 21% increase DNA production, 50-60% incorporation [14C]proline into collagenous and noncollagenous proteins, 200% alkaline phosphatase activity; under identical conditions, [35S]sulfate proteoglycans (glycosaminoglycans) was not affected. These results suggest that may be important maintaining or stimulating the osteogenic phenotype normal cells.
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