Targeting hyaluronan of the endothelial glycocalyx for therapeutic intervention.
作者： Caroline P D Wheeler-Jones , Andrew A Pitsillides , Charlotte E Farrar
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摘要: The endothelial glycocalyx (EG) is an extracellular matrix (ECM) coating the luminal surface of vascular endothelium. Hyaluronan (HA), a glycosaminoglycan, important constituent EG that regulates inflammation and repair. By providing direct link between endothelium its ECM, HA contributes to maintaining integrity; emerging evidence indicates close association deterioration, concomitant loss onset dysfunction, phenomenon involved in many disorders, including atherosclerosis, diabetes, hypertension dyslipidemia. This review provides overview modification by pathological stimuli considers potential pharmacological targeting synthesis binding limit dysfunction improve vasculoprotection.
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