The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia
作者： George A. Calin , Yuri Pekarsky , Carlo M. Croce
DOI: 10.1016/J.BEHA.2007.02.003
关键词:
摘要: New findings support the view that chronic lymphocytic leukemia (CLL) is a genetic disease in which main alterations occur new class of genes named microRNAs (miRNAs). Cases with good prognostic features typically are characterized by miRNA down-regulation miR-15a and miR-16-1 , located at 13q14.3. Both negatively regulate BCL2 post-transcriptional level. On other hand, CLL cases use unmutated immunoglobulin heavy-chain variable-region ( IgV H ) or have high-level expression 70-kD zeta-associated protein (ZAP-70) high levels TCL1 due to low-level miR-29 miR-181 directly target this oncogene. Conceivably, these miRNAs might be used for therapy disease.
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