Down-regulation of KIAA1199/CEMIP by miR-216a suppresses tumor invasion and metastasis in colorectal cancer.

摘要: Colorectal cancer is one of the major causes death from cancer. Metastasis leading cause treatment failure, in which stem cells and circulating tumor play crucial roles. Identifying involved metastatic biomarkers clarifying regulation mechanisms are great importance for targeting metastasis. In current research, we discovered that KIAA1199, a cell-migration inducing protein, showed higher expression CD44+ compared with paired primary tissues, was upregulated colorectal positively correlated numbers mesenchymal phenotype cells, predicted shorter progress-free survival. Moreover, indicated down-regulation KIAA1199 suppressed migration invasion vitro, inhibited metastasis vivo. Furthermore, demonstrated direct functional targets miR-216a, miR-216a overexpression led to decreased Collectively, plays critical role maintaining an aggressive suppression KIAA1199-related motilities contributes reduced