L-Arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex

摘要: Microinjection of N-methyl-D-aspartate (NMDA; 1 and 2.5 nmol) or kainate (KA; 50 pmol) into the deep prepiriform cortex elicited behavioral signs seizure activity. No epileptiform activity was observed after microinjection either L-arginine (L-Arg, 5 10 its D-enantiomer, D-arginine (D-Arg, 2.5–10 nmol). However, both score incidence electroencephalographic (EEG) epileptic discharges NMDA (1 KA (50 were significantly increased by L- but not D-Arg. The facilitatory effects L-Arg on dose-dependent could be prevented co-administration (10 nitric oxide (NO) synthase inhibitor, Nω-nitro-L-arginine methyl ester (L-NAME, 20 Motor electrocortical seizures NO donor sodium nitroprusside (SNP; to cortex. Infusion methylene blue (20 nmol), a soluble guanylate cyclase protected against SNP-induced seizures. Furthermore, prior infusion subconvulsant dose SNP potentiated pmol). These results support proposal that is formed from upon excitatory amino acid receptor activation within cortex, thereby contributing genesis