Intracellular Arsenic Speciation and Quantification in Human Urothelial and Hepatic Cells

作者: Ricarda Zdrenka , Joerg Hippler , Georg Johnen , Alfred V. , Elke Dopp

DOI: 10.5772/29717

关键词:

摘要: Arsenic can be found in nearly every part of the geosphere. It is viewed as most harmful toxin drinking water worldwide. At many places on earth contains concentrations above 10 μg/l, which significantly exceed tolerable value recommended by WHO (World health organization [WHO], 2001). This considered a threat for millions people, especially Bangladesh, Vietnam, and Latin America, where geogenic origin has already been proved (Ng et al., 2003). The sources this considerable arsenic occurrence (Fig. 1) are (erosion), mining activities, geothermal waters (Smedly & Kinniburgh, 2002).

参考文章(63)
Albert W. Rettenmeier, Alfred V. Hirner, 14 Methylated Metal(loid) Species in Humans Metal ions in life sciences. ,vol. 7, pp. 465- 521 ,(2010) , 10.1039/BK9781847551771-00465
Poul Erik Petersen, The burden of oral disease: challenges to improving oral health in the 21st century. Bulletin of The World Health Organization. ,vol. 83, pp. 3- 3 ,(2005) , 10.1590/S0042-96862005000100003
E. Dopp, L.M. Hartmann, A.-M. Florea, U. von Recklinghausen, R. Pieper, B. Shokouhi, A.W. Rettenmeier, A.V. Hirner, G. Obe, Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells Toxicology and Applied Pharmacology. ,vol. 201, pp. 156- 165 ,(2004) , 10.1016/J.TAAP.2004.05.017
Miroslav Stýblo, Zuzana Drobná, Ilona Jaspers, Shan Lin, David J Thomas, The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environmental Health Perspectives. ,vol. 110, pp. 767- 771 ,(2002) , 10.1289/EHP.110-1241242
Mary E Anderson, Glutathione: an overview of biosynthesis and modulation. Chemico-Biological Interactions. ,vol. 111112, pp. 1- 14 ,(1998) , 10.1016/S0009-2797(97)00146-4
Ya-ping Yang, Zhong-qin Liang, Bo Gao, Yan-li Jia, Zheng-hong Qin, Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells Acta Pharmacologica Sinica. ,vol. 29, pp. 123- 134 ,(2008) , 10.1111/J.1745-7254.2008.00732.X
Hua Naranmandura, Noriyuki Suzuki, Kazuo T. Suzuki, Trivalent arsenicals are bound to proteins during reductive methylation. Chemical Research in Toxicology. ,vol. 19, pp. 1010- 1018 ,(2006) , 10.1021/TX060053F
A. Hartwig, H. Blessing, T. Schwerdtle, I. Walter, Modulation of DNA repair processes by arsenic and selenium compounds Toxicology. ,vol. 193, pp. 161- 169 ,(2003) , 10.1016/J.TOX.2003.08.004