Ferritins in Chordata: Potential evolutionary trajectory marked by discrete selective pressures

摘要: Ferritins (FTs) are iron storage proteins that involved in managing iron-oxygen balance. In our work, we present a hypothesis on the putative effect of geological changes have affected evolution and radiation ferritin proteins. Based sequence analysis phylogeny reconstruction, hypothesize two significant factors been proteins: fluctuations atmospheric oxygen concentrations, altering redox potential, changing availability water rich bioavailable ferric ions. Fish, ancient amphibians, reptiles, placental mammals developed broadest repertoire singular FTs, attributable to embryonic growth aquatic environments containing low levels abundant forms soluble iron. contrast, oviparous land vertebrates, like reptiles birds, high limited environmental Fe2+ exhibit lower diversity but display broad subfamilies, particularly notable early reptiles.