Frontiers in Suicide Gene Therapy of Cancer

摘要: The National Cancer Institute (NCI) and the American Society (ACS) predict that 1,638,910 men women will be diagnosed with cancer in USA 2012. Nearly 577,190 patients die of all sites this year. Patients undergoing current systemic therapies suffer multiple side effects from nausea to infertility. Potential parents, when cancer, have deposit oocytes sperms prior starting radiation or chemo-therapy for future genetic testing vitro fertilization, while trying avoid risks iatrogenic mutations their germ cells. Otherwise, children parents treated therapies, at high risk developing disorders. According these predictions, year carry another, very poor therapeutic record again. ultimate goal therapy is complete elimination cells, leaving healthy cells unharmed. One most promising strategies regard suicide gene (CSGT), which rapidly progressing into new frontiers. success, CSGT, primarily contingent upon precision delivery transgenes only. This addressed by discovering targeting unique / over-expressed biomarkers displayed on stem Specificity further enhanced designing DNA constructs, put genes under control cell specific promoters. suicidal involves viral, as well synthetic vectors, are guided antibodies ligands. options also include engineered tropisms towards cancers. Main mechanisms inducing cells’ deaths include: transgenic expression thymidine kinases, cytosine deaminases, intracellular antibodies, telomeraseses, caspases, DNases. Precautions undertaken eliminate associated transgenesis. Progress genomics proteomics should help us identifying metabolic pathways clinical trials targeted personalized cancer.