Induction of cerebral gliomas in rats with dietary lead subacetate and 2-acetylaminofluorene.

摘要: Summary In a study of neoplasms induced by 2-acetylaminofluorene (2-AAF) and lead subacetate, 25 gliomas 3 extracerebral intracranial tumors were found in 988 Wistar cesarean-delivered (Sprague-Dawley) rats, which 663 experimental 325 control groups. The usually developed after 52 weeks age. Most classified as poorly differentiated malignant gliomas. highest incidence (8.6%) was animals ingesting subacetate the difference compared with (0.3%) among controls statistically significant ( p