Role of IL-12/IL-23 in the Pathogenesis of Multiple Sclerosis

摘要: Publisher Summary Multiple sclerosis (MS) is a T-cell-mediated autoimmune disease of the central nervous system (CNS) with complex genetic background. It generally accepted that MS begins formation acute inflammatory lesions were mediated by autoreactive T cells and B because breakdown blood–brain barrier (BBB). The demyelinating plaques dominated activated macrophages associated oligodendrocyte destruction. IL-12 IL-23 are two heterodimeric cytokines belonging to p40 family, which plays an important role in regulating T-cell responses. They both heterodimers subunits. heterodimer p35 p40, whereas p19 p40. share common subunit, Both mainly produced antigen-presenting (APCs), including macrophages, dendritic cells, exerted their biologic functions on CD4 cells. receptor receptors. â1 chain. consists chain â2 chain, while second called receptor. drives naive CD4? differentiate into IFN-a- producing Th-1 lineage, promotes IL-17-producing Th-17 lineage. IL-12-driven IL-23-driven believed contribute significantly pathogenesis EAE.