Inhibition by cyclosporin A of rodent malaria in vivo and human malaria in vitro.

摘要: The development and course of normally lethal parasitemias in mice inoculated intraperitoneally with erythrocytic stages Plasmodium yoelii or berghei were markedly affected by treatment the antilymphoid drug cyclosporin A (CS-A). When first four daily subcutaneous 25-mg/kg doses CS-A was given at time parasite inoculation, patent infections failed to develop. If begun up 5 days earlier, this same regimen prolonged prepatent period, attenuated parasitemia, reduced mortality. In patient infections, two consecutive sufficient terminate which, after several days, reappeared but self-limiting. This pattern apparent cure followed transient recrudescence remained unaltered even when dose continued for 3 weeks. Recrudescence associated emergence populations that relatively resistant and, case P. yoelii, virulence. more limited experiments, found be active vitro against human malarial palsmodium falciparum. Depending on concentration culture medium, growth either prevented inhibited.