Interaction of substance P, compound 4880 and mastoparan with the α-subunit C-terminus of G protein

作者: M. Mousli , C. Bronner , J. Bockaert , B. Rouot , Yves Landry

DOI: 10.1016/0165-2478(90)90207-7

关键词:

摘要: Pretreatment of purified calf brain G proteins with activated pertussis toxin or antibodies raised against the C-terminus their alpha subunits prevented increase in GTPase activity induced by substance P, compound 48/80 and mastoparan. These results suggest that these mast cell secretagogues activate directly via an interaction mimicking agonist-liganded receptors.

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