α-Allenyl Ethers as Starting Materials for Palladium Catalyzed Suzuki-Miyaura Couplings of Allenylphosphine Oxides with Arylboronic Acids.

摘要: We disclose here the first palladium-catalyzed Suzuki–Miyaura couplings of aryl ethers functionalized allenylphosphine oxides with arylboronic acids. This new methodology α-allenyl as starting materials provides a novel approach to generate phosphinoyl 1,3-butadienes and derivatives medium excellent yields. The reaction tolerates variety functional groups afford ranges structurally diverse substituted phosphionyl 1,3-butadienes. For unsymmetrical allene substrates, high stereospecific additions give E-isomers are usually observed. On basis known palladium chemistry, mechanism is proposed.