Antioxidant activity of synthetic cytokinin analogues: 6-alkynyl- and 6-alkenylpurines as novel 15-Lipoxygenase inhibitors.
作者： Anders Bråthe , Geir Andresen , Lise-Lotte Gundersen , Karl E. Malterud , Frode Rise
DOI: 10.1016/S0968-0896(01)00427-8
关键词:
摘要: Synthetic cytokinin analogues as well the known CKs 6-benzylaminopurine (BAP), kinetin and trans-zeatin were examined for antioxidant activity. The compounds tested potential diphenylpicrylhydrazyl (DPPH) scavengers inhibitors of 15-lipoxygenase (15-LO). natural plant hormones essentially inactive in both assays, but several synthetic have a profound inhibiting effect on from soybeans. same only weak DPPH they may therefore be regarded so-called non 15-LO.
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sci-hub.se 参考文章(28)
Hartmut Kuhn, Bernd J Thiele, The diversity of the lipoxygenase family. Many sequence data but little information on biological significance. FEBS Letters. ,vol. 449, pp. 7- 11 ,(1999) , 10.1016/S0014-5793(99)00396-8
Barry Halliwell, DRUG ANTIOXIDANT EFFECTS-A BASIS FOR DRUG SELECTION Drugs. ,vol. 42, pp. 569- 605 ,(1991) , 10.2165/00003495-199142040-00003
Daniel Steinberg, At last, direct evidence that lipoxygenases play a role in atherogenesis. Journal of Clinical Investigation. ,vol. 103, pp. 1487- 1488 ,(1999) , 10.1172/JCI7298
Karl E. Malterud, Kjersti M. Rydland, Inhibitors of 15-lipoxygenase from orange peel. Journal of Agricultural and Food Chemistry. ,vol. 48, pp. 5576- 5580 ,(2000) , 10.1021/JF000613V
Karl Egil Malterud, Tove Lynn Farbrot, Anne Elisabeth Huse, Reidar Bredo Sund, Antioxidant and Radical Scavenging Effects of Anthraquinones and Anthrones Pharmacology. ,vol. 47, pp. 77- 85 ,(1993) , 10.1159/000139846
Geir Andresen, Aud Berglen Eriksen, Bjørn Dalhus, Lise-Lotte Gundersen, Frode Rise, Synthesis of 6-substituted purin-2-ones with potential cytokinin activity Journal of The Chemical Society-perkin Transactions 1. pp. 1662- 1672 ,(2001) , 10.1039/B101327K
Barry Halliwell, John M. C. Gutteridge, Free radicals in biology and medicine ,(1985)
Aryeh A. Frimer, Gladis Aljadeff, Joseph Ziv, Reaction of (arylmethyl)amines with superoxide anion radical in aprotic media. Insights into cytokinin senescence inhibition Journal of Organic Chemistry. ,vol. 14, pp. 1700- 1705 ,(1983) , 10.1021/JO00158A023
Leslie Crombie, Kamlesh M. Mistry, Synthesis of 12-oxophytodienoic acid (12-oxoPDA), metabolic parent of OPC-compounds and epi-jasmonic acid Journal of The Chemical Society, Chemical Communications. pp. 537- 539 ,(1988) , 10.1039/C39880000537
Rajkumar Kumarathasan, Frans HH Leenen, Is ATP a substrate for 15-lipoxygenase? Biochemistry and Cell Biology. ,vol. 78, pp. 87- 91 ,(2000) , 10.1139/O99-073