Interstitial lung disease in Japanese patients with lung cancer: a cohort and nested case-control study.
作者： Shoji Kudoh , Harubumi Kato , Yutaka Nishiwaki , Masahiro Fukuoka , Kouichiro Nakata
DOI: 10.1164/RCCM.200710-1501OC
关键词:
摘要: Rationale: Interstitial lung disease (ILD) occurs in Japanese patients with non–small cell lung cancer (NSCLC) receiving gefitinib. Objectives: To elucidate risk factors for ILD in Japanese patients with NSCLC during treatment with gefitinib or chemotherapy. Methods: In a prospective epidemiologic cohort, 3,166 Japanese patients with advanced/recurrent NSCLC were followed for 12 weeks on 250 mg gefitinib (n= 1,872 treatment periods) or chemotherapy (n= 2,551). Patients who developed acute ILD (n= 122) and randomly …
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