Oocyte-somatic cell communication in the ovarian follicles of mammals

摘要: Abstract This paper reviews the communication between developing follicular germ cell, oocyte, and its companion somatic cells, granulosa cells. Both gap junctions paracrine factors mediate this communication. Direct transfer of low molecular weight through is essential for oocyte growth regulation meiosis. Paracrine secreted by such as c-kit ligand, also participate in these processes. Oocytes secrete that affect organization, cell proliferation, ability cumulus cells to produce hyaluronic acid. Thus bidirectional components ovarian follicle development function both.