Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules.

摘要: Aging is characterized by the progressive accumulation of degenerative changes, culminating in impaired function and increased probability death. It major risk factor for many human pathologies – including cancer, type 2 diabetes, cardiovascular neurodegenerative diseases consequently exerts an enormous social economic toll. The goal aging research to develop interventions that can delay onset multiple age-related prolong healthy lifespan (healthspan). observation enhanced longevity health be achieved model organisms dietary restriction or simple genetic manipulations has prompted hunt chemical compounds increase lifespan. Most pathways modulate rate mammals have homologs yeast, flies, worms, suggesting initial screening identify such pharmacological may possible using invertebrate models. In recent years, several been identified extend invertebrates, even rodents. Here, we summarize strategies employed, progress made, identifying capable extending ranging from invertebrates mice discuss formidable challenges translating this work therapies.