In situ extractive fermentation of acetone and butanol

摘要: The productivity of the acetone-butanol fermentation was increased by continuously removing acetone and butanol from broth during fed-batch culture. Whole containing viable cells Clostridium acetobutylicum cycled to a Karr reciprocating plate extraction column in which were extracted into oleyl alcohol flowing counter-currently through column. By these toxic metabolites broth, end product inhibition reduced, concentrated feed solution 300 g/L glucose fermented at an overall 1.0 h, 70% higher than normal batch fermentation. continuous process provides flexible operation lends itself scale-up.