Decreased thermal tolerance in Mus musculus with melatonin and chlorpromazine
作者： Victor H. Hutchison , Ninette Hart
DOI: 10.1016/0742-8413(84)90101-4
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摘要: Abstract 1. Adult Mus musculus , previously acclimatized for two weeks to 25°C and an LD 12:12 photoperiod, were injected (i.p.) with daily doses of melatonin (4.0 mg) or chlorpromazine (20.0 mg kg −1 ) 2 days. 2. Both drugs significantly reduced the critical thermal maximum (CTM) elevated defended temperature (EDT). 3. Melatonin increased length EDT but had no effect on EDT. 4. reduce tolerance in ectotherms, this is apparently first demonstration that increase sensitivity high endotherm.
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