Racial Differences in the Expression of Shared Idiotypes by Paraproteins from Patients with Monoclonal Gammopathies

作者: J. R. Berenson , A. K. Lichtenstein , J. Cao , S. Hart , D. Palomares

DOI: 10.1007/978-3-642-76655-8_15

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摘要: Twenty-nine murine monoclonal antibodies have been produced which react with shared idiotypes expressed by B-cell lymphomas and leukemias. We tested this panel of for reactivity the paraproteins from 37 patients multiple myeloma 13 gammopathy undetermined significance (MGUS). Fourteen 50 reacted at least one antibody in anti-idiotypic antibodies. Seven different anti-idiotypes demonstrated paraproteins. A similar frequency was found both MGUS proteins. One antibody, S30–47, eight (16%) these gammopathies; whereas, anti-idiotype only bound to 3% non-Hodgkin’s no cases chronic lymphocytic leukemia. This obtained nearly one-third black but none white patients’ showed antiidiotype. In each eleven tested, plasma cells isolated bone marrow were shown be reactive same we paraprotein. Anti-shared idiotype may provide useful reagents studies gammopathies.

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