Organization and Function of the Growth Hormone Gene Cluster
作者： John S. Parks
DOI: 10.1007/978-1-4615-7201-5_17
关键词:
摘要: The human growth hormone (hGH) gene cluster contains genes coding for hGH and chorionic somatomammotropin (hCS, also known as placental lactogen) together with related that do not code familiar hormones. Intensive molecular genetic investigation over the past 6 years has established mRNA sequences both hormones, chromosomal location regional organization of cluster, DNA all within cluster. Understanding structure explained synthesis 20K suggested possibility a new peptide to hGH. mechanisms responsible tissue-specific expression have begun be unraveled. Discovery hCS deletions in several heritable disorders clarified roles hormones physiology.
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G F Saunders, M E Harper, H A Barrera-Saldaña, Chromosomal localization of the human placental lactogen-growth hormone gene cluster to 17q22-24. American Journal of Human Genetics. ,vol. 34, pp. 227- 234 ,(1982)
V J Kidd, G F Saunders, Linkage arrangement of human placental lactogen and growth hormone genes. Journal of Biological Chemistry. ,vol. 257, pp. 10673- 10680 ,(1982) , 10.1016/S0021-9258(18)33875-4
H A Barrera-Saldaña, P H Seeburg, G F Saunders, Two structurally different genes produce the same secreted human placental lactogen hormone. Journal of Biological Chemistry. ,vol. 258, pp. 3787- 3793 ,(1983) , 10.1016/S0021-9258(18)32734-0
Peter Vest Nielsen, Henning Pedersen, Else-Marie Kampmann, Absence of human placental lactogen in an otherwise uneventful pregnancy American Journal of Obstetrics and Gynecology. ,vol. 135, pp. 322- 326 ,(1979) , 10.1016/0002-9378(79)90698-7
Frances M. DeNoto, David D. Moore, Howard M. Goodman, Human growth hormone DNA sequence and mRNA structure: possible alternative splicing Nucleic Acids Research. ,vol. 9, pp. 3719- 3730 ,(1981) , 10.1093/NAR/9.15.3719
J A Phillips, J S Parks, B L Hjelle, J E Herd, L P Plotnick, C J Migeon, P H Seeburg, Genetic analysis of familial isolated growth hormone deficiency type I. Journal of Clinical Investigation. ,vol. 70, pp. 489- 495 ,(1982) , 10.1172/JCI110640
David D. Moore, Mark A. Conkling, Howard M. Goodman, Human growth hormone: A multigene family Cell. ,vol. 29, pp. 285- 286 ,(1982) , 10.1016/0092-8674(82)90144-1
NAOMI HIZUKA, CARLA M. HENDRICKS, GEORGE N. PAVLAKIS, DEAN H. HAMER, PHILLIP GORDEN, Properties of human growth hormone polypeptides: purified from pituitary extracts and synthesized in monkey kidney cells and bacteria. The Journal of Clinical Endocrinology and Metabolism. ,vol. 55, pp. 545- 550 ,(1982) , 10.1210/JCEM-55-3-545
Brian L. Hjelle, John A. Phillips, Peter H. Seeburg, Relative levels of methylation in human growth hormone and chorionic somatomammotropin genes in expressing and non-expressing tissues Nucleic Acids Research. ,vol. 10, pp. 3459- 3474 ,(1982) , 10.1093/NAR/10.11.3459
PETER H. SEEBURG, The Human Growth Hormone Gene Family: Nucleotide Sequences Show Recent Divergence and Predict a New Polypeptide Hormone DNA (Mary Ann Liebert, Inc.). ,vol. 1, pp. 239- 249 ,(1982) , 10.1089/DNA.1.1982.1.239