Antimicrobial resistance among invasive Haemophilus influenzae strains: results of a Brazilian study carried out from 1996 through 2000

摘要: A total of 1712 strains Haemophilus influenzae isolated from patients with invasive diseases were obtained ten Brazilian states 1996 to 2000. s-Lactamase production was assessed and the minimum inhibitory concentrations (MIC) ampicillin, chloramphenicol, ceftriaxone rifampin determined using a method for broth microdilution test medium. The prevalence producing s-lactamase ranged 6.6 57.7%, an overall 18.4%. High frequency s-lactamase-mediated ampicillin resistance observed in Distrito Federal (25%), Sao Paulo (21.7%) Parana (18.5%). Of analyzed, none negative, resistant. 16.8% resistant 13.8% these also presented only 3.0% chloramphenicol alone. All susceptible MIC90 0.015 µg/ml 0.25 µg/ml, respectively. Ceftriaxone is drug choice empirical treatment bacterial meningitis pediatric who have not been screened susceptibility. emergence serious challenge management H. disease, which emphasizes fundamental role laboratory-based surveillance antimicrobial resistance.