Fully automated synthesis of the M1 receptor agonist [11C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system
作者： Mickael Huiban , Sabina Pampols-Maso , Jan Passchier
DOI: 10.1016/J.APRADISO.2011.05.007
关键词:
摘要: Abstract A fully automated and GMP compatible synthesis has been developed to reliably label the M1 receptor agonist GSK1034702 with carbon-11. Stille reaction of trimethylstannyl precursor [11C]methyl iodide afforded [11C]GSK1034702 in an estimated 10±3% decay corrected yield. This method utilises commercially available modular laboratory equipment provides high purity a formulation suitable for human use.
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