Interaction between nonsteroidal anti-inflammatory drugs and biological membranes-IV. Effects of nonsteroidal anti-inflammatory drugs and of various ions on the availability of sulfhydryl groups on lymphoid cells and mitochondrial membranes.
作者： Jean-Pierre Famaey , Michael W. Whitehouse
DOI: 10.1016/0006-2952(75)90088-X
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摘要: Abstract A stimulation effect of various nonsteroidal anti-inflammatory drugs (NSAID) on a sulfhyd-ryl-disulfide interchange reaction between serum protein sulfhydryl groups and 5,5'-dithiobis-(2-nitro-benzoic) acid (DTNB) has been described. We now describe similar 65 μM DTNB in rat, rabbit human lymphocyte membranes rat liver mitochondria. This is greatly accelerated the presence ten different NSAID. The this sulfhydryl-disulfide appears to be dependent drug concentration. It also closely related ionic composition incubation medium which, by itself, according specific cationic anionic sequences, influences availability membranes. 0·6 mM carboxypyridine disulfide (CPDS), which another molecule able react specifically with membranes, affected way According well known involvement inflammatory reactions, peculiar NSAID membrane groups, especially lymphoid cells, could some their clinical properties.
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