Current Perspectives and Mechanisms of Relationship between Intestinal Microbiota Dysfunction and Dementia: A Review.

摘要: Background Accumulating data suggest a crucial role of the intestinal microbiota in development and progression neurodegenerative diseases. More recently, emerging reports have revealed an association between dysfunctions dementia, debilitating multifactorial disorder, characterized by progressive deterioration cognition behavior that interferes with social professional life sufferer. However, mechanisms this are not fully understood. Summary In review, I discuss recent cross-talk dysfunction brain underlie dementia. Potential therapeutic options for dementia also discussed. The pleiotropic signaling metabolic products together their specific roles maintenance both blood-brain barriers as well regulation local, distant, circulating immunocytes, enteric, visceral, central neural functions integral to healthy gut brain. Key messages Research investigating effect on health should focus multiple interrelated systems involving local neuroendocrine, immunocyte, microbial transmitters neurohumoral cells only maintain intestinal, but blood brain-barrier integrity. change microbiome/dysbiome repertoire is