Nitric oxide: an antioxidant and neuroprotector.

摘要: Indirect evidence, including neuroprotection against 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP)-neurotoxicity by nitric oxide synthase (NOS) inhibitors and resistance of transgenic animals deficient in NOS, is controversial. We have reviewed evidence favor oxidative stress during the development MPTP-neurotoxicity the influence antioxidants, including (NO) NO donors, on MPTP-induced dopaminergic neurotoxicity. Systemic administration MPTP causes dose-dependent generation of hydroxyl radicals (OH) in vivo in striatum mice; OH scavengers protect dopaminergic neurons from this insult. On other hand role of is Hitherto, no direct for the involvement neurotoxicity has been available. does not affect inducible-NOS mRNA level or its expression SN striatum. Nitroglycerine, a donor, can attenuate dopamine depletion in virtue scavenging action. Several donors have also shown to scavenge generated, following Fenton chemistry in vitro , protect against in vivo dopaminergic small mass iron complex formation. This suggests that renders protection against OH-mediated nigrostriatal lesions, acting as an antioxidant.