Association of the 399Arg/Gln XRCC1, the 194 Arg/Trp XRCC1, the 326Ser/Cys OGG1, and the 324Gln/His MUTYH gene polymorphisms with clinical parameters and the risk for development of primary open-angle glaucoma

摘要: Abstract Background Numerous data have shown that progressive loss of human trabecular meshwork (TM) cells may be connected with oxidative stress. This hypothesis suggest an association base excision repair the risk primary open angle glaucoma development. Purpose The aim this study was to evaluate role 399Arg/Gln XRCC1 , 194 Arg/Trp 326SerCys OGG1 and 324Gln/His MUTYH gene polymorphisms clinical parameters for development POAG. Methods Our research included 170 patients POAG 193 healthy controls. Gene were investigated by PCR-RFLP. Heidelberg Retinal Tomography (HRT) also analyzed. Results genotype associated increased (OR 2.50; 95% CI, 1.54–4.07, P  = 0.0002). 399Gln/Gln increase progression according such as cup/disk ratio (c/d) 1.93; 1–3.73,  = 0.04) Rim area (RA factor) 3.88; 1.01–14.82,  = 0.04). Moreover, found retinal nerve-fiber layer (RNFL distribution 2.46; 1.06–5.68,  = 0.03). In contrast, analysis polymorphism in patient group RA factor showed it reduce 0.14; 0.02–0.89,  = 0.05). current demonstrates between 326Ser/Cys 326Cys allele gene, addition, presence 326His progression, VF parameter 2.57; 1.47–4.57,  = 0.0001). Conclusion We 399Gln factors we postulate 399 Arg/Gln 326 Ser/Cys 324 Gln/His genes