Mind the gap: A survey of how cancer drug carriers are susceptible to the gap between research and practice
作者： Darren Lars Stirland , Joseph W. Nichols , Seiji Miura , You Han Bae
DOI: 10.1016/J.JCONREL.2013.09.026
关键词:
摘要: With countless research papers using preclinical models and showing the superiority of nanoparticle design over current drug therapies used to treat cancers, it is surprising how deficient translation these nano-sized carriers into clinical setting is. This review article seeks compare results for Doxil®, PK1, Abraxane®, Genexol-PM®, Xyotax™, NC-6004, Mylotarg®, PK2, CALAA-01. While not comprehensive, covers designed improve efficacy common drugs in chemotherapy. always available or comparable, effort was made pharmacokinetics, toxicity, between animal human studies. Discussion provided suggest what might be causing gap. Finally, suggestions encouragement are dispensed potential that hold.
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