PPARs in the Control of Uncoupling Proteins Gene Expression.
作者： Francesc Villarroya , Roser Iglesias , Marta Giralt
DOI: 10.1155/2007/74364
关键词:
摘要: Uncoupling proteins (UCPs) are mitochondrial membrane transporters involved in the control of energy conversion mitochondria. Experimental and genetic evidence relate dysfunctions UCPs with metabolic syndrome obesity. The PPAR subtypes mediate to a large extent transcriptional regulation UCP genes, distinct relevance depending on gene tissue which it is expressed. UCP1 under dual PPARγ PPARα relation brown adipocyte differentiation lipid oxidation, respectively. UCP3 regulated by PPARδ muscle, heart, adipose tissues. UCP2 also PPARs even tissues predominantly expressed (eg, pancreas liver). This review summarizes current understanding role expression normal conditions context type-2 diabetes or
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Frédéric Bouillaud, Francesc Villarroya, Eliane Hentz, Serge Raimbault, Anne-Marie Cassard, Daniel Ricquier, Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe. Clinical Science. ,vol. 75, pp. 21- 27 ,(1988) , 10.1042/CS0750021
Jing-yan TIAN, Guo LI, Yan-yun GU, Hong-li ZHANG, Wen-zhong ZHOU, Xiao WANG, Hong-da ZHU, Tian-hong LUO, Min LUO, Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets. Chinese Medical Journal. ,vol. 119, pp. 574- 580 ,(2006) , 10.1097/00029330-200604010-00010
Y.-T. Zhou, M. Shimabukuro, M.-Y. Wang, Y. Lee, M. Higa, J. L. Milburn, C. B. Newgard, R. H. Unger, Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 8898- 8903 ,(1998) , 10.1073/PNAS.95.15.8898
M. Carmen Carmona, Roser Iglesias, Marı́a-Jesús Obregón, Gretchen J. Darlington, Francesc Villarroya, Marta Giralt, Mitochondrial Biogenesis and Thyroid Status Maturation in Brown Fat Require CCAAT/Enhancer-binding Protein α Journal of Biological Chemistry. ,vol. 277, pp. 21489- 21498 ,(2002) , 10.1074/JBC.M201710200
Rosa ALVAREZ, MaLuz CHECA, Sonia BRUN, Octavi VI±AS, Teresa MAMPEL, Roser IGLESIAS, Marta GIRALT, Francesc VILLARROYA, Both retinoic-acid-receptor- and retinoid-X-receptor-dependent signalling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids. Biochemical Journal. ,vol. 345, pp. 91- 97 ,(2000) , 10.1042/BJ3450091
Teruyo Nakatani, Nobuyo Tsuboyama-Kasaoka, Mayumi Takahashi, Shinji Miura, Osamu Ezaki, Mechanism for Peroxisome Proliferator-activated Receptor-α Activator-induced Up-regulation of UCP2 mRNA in Rodent Hepatocytes Journal of Biological Chemistry. ,vol. 277, pp. 9562- 9569 ,(2002) , 10.1074/JBC.M110132200
Emmanuel Chevillotte, Jennifer Rieusset, Marina Roques, Michel Desage, Hubert Vidal, The Regulation of Uncoupling Protein-2 Gene Expression by ω-6 Polyunsaturated Fatty Acids in Human Skeletal Muscle Cells Involves Multiple Pathways, Including the Nuclear Receptor Peroxisome Proliferator-activated Receptor β Journal of Biological Chemistry. ,vol. 276, pp. 10853- 10860 ,(2001) , 10.1074/JBC.M008010200
Angel Valmaseda, M.Carmen Carmona, M.José Barberá, Octavi Viñas, Teresa Mampel, Roser Iglesias, Francesc Villarroya, Marta Giralt, Opposite regulation of PPAR-α and -γ gene expression by both their ligands and retinoic acid in brown adipocytes Molecular and Cellular Endocrinology. ,vol. 154, pp. 101- 109 ,(1999) , 10.1016/S0303-7207(99)00081-7
Hannes Oberkofler, Kerstin Klein, Thomas K. Felder, Franz Krempler, Wolfgang Patsch, Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells. Endocrinology. ,vol. 147, pp. 966- 976 ,(2006) , 10.1210/EN.2005-0817
Zhidan Wu, Pere Puigserver, Ulf Andersson, Chenyu Zhang, Guillaume Adelmant, Vamsi Mootha, Amy Troy, Saverio Cinti, Bradford Lowell, Richard C. Scarpulla, Bruce M. Spiegelman, Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 Cell. ,vol. 98, pp. 115- 124 ,(1999) , 10.1016/S0092-8674(00)80611-X