Clostridium difficile infection: responses, relapses and re-infections

作者: M.H. Wilcox , R.C. Spencer

DOI: 10.1016/0195-6701(92)90092-Z

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摘要: Abstract Clostridium difficile infection is a common and potentially lethal complication of antibiotic usage. Since the aetiology antibiotic-associated colitis was discovered 14 years ago, two antibiotics in particular, metronidazole vancomycin, have been used to treat C. infection. Studies comparing efficacy these are reviewed. It now apparent that many so-called ‘relapses' following treatment are, fact, re-infections. Such findings major control implications.

参考文章(42)
S. Cronberg, B. Castor, A. Thorén, Fusidic acid for the treatment of antibiotic-associated colitis induced by clostridium difficile Infection. ,vol. 12, pp. 276- 279 ,(1984) , 10.1007/BF01645961
Tedesco Fj, Treatment of recurrent antibiotic-associated pseudomembranous colitis. The American Journal of Gastroenterology. ,vol. 77, pp. 220- 221 ,(1982)
E W Kreutzer, F D Milligan, Treatment of antibiotic-associated pseudomembranous colitis with cholestyramine resin. The Johns Hopkins medical journal. ,vol. 143, pp. 67- 72 ,(1978)
Rial D. Rolfe, Sydney M. Finegold, Clostridium difficile : its role in intestinal disease Academic Press. ,(1988)
Graeme P. Young, Peter B. Ward, Noel Bayley, David Gordon, Geoff Higgins, Joseph A. Trapani, Malcolm I. McDonald, Justin Labrooy, Robert Hecker, Antibiotic-associated colitis due to Clostridium difficile: double-blind comparison of vancomycin with bacitracin. Gastroenterology. ,vol. 89, pp. 1038- 1045 ,(1985) , 10.1016/0016-5085(85)90206-9
Raeleen D. Cherry, David Portnoy, Mansour Jabbari, Donald S. Daly, Douglas G. Kinnear, Carl A. Goresky, Metronidazole: An Alternate Therapy for Antibiotic-Associated Colitis Gastroenterology. ,vol. 82, pp. 849- 851 ,(1982) , 10.1016/S0016-5085(82)80244-8
John G. Bartlett, Francis J. Tedesco, Steward Shull, Bruce Lowe, Tewen Chang, Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis Gastroenterology. ,vol. 78, pp. 431- 434 ,(1980) , 10.1016/0016-5085(80)90851-3
BradleyS. Bender, BarbaraE. Laughon, Charlotte Gaydos, MichaelS. Forman, Richard Bennett, W.B. Greenough, StephenD. Sears, JohnG. Bartlett, Is Clostridium difficile endemic in chronic-care facilities? The Lancet. ,vol. 328, pp. 11- 13 ,(1986) , 10.1016/S0140-6736(86)92559-6
J. Silva, D.H. Batts, R. Fekety, J.F. Plouffe, G.D. Rifkin, I. Baird, Treatment of Clostridium difficile colitis and diarrhea with vancomycin The American Journal of Medicine. ,vol. 71, pp. 815- 822 ,(1981) , 10.1016/0002-9343(81)90369-7