作者: Lina Zhang , Qibin Zhang
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摘要: Purpose Glycated hemoglobin (HbA1c) is used clinically for diagnosis and therapeutic management of diabetes. However, HbA1c reflects average blood glucose level over a long period. The aim this study to look short period, more sensitive protein markers that correlate better with glycemic level. Experimental design glycated proteome human plasma from type 1 diabetic individuals good poor (n = 20 each) control are analyzed using an online two-dimensional proteomics approach. Selected peptides further validated their potential as candidate biomarkers parallel reaction monitoring. Results 305 quantified 290 significantly increased in samples control. 76 the 88 selected have receiver operating characteristic area under curve (AUC) values greater than 0.8. Six high AUC show correlation higher fold changes between HbA1c. parent proteins half-lives shorter Conclusions clinical relevance Using advanced platform glycation analysis, identified promising sensitive, term indicators patients commonly