Identification of VHY/Dusp15 as a Regulator of Oligodendrocyte Differentiation through a Systematic Genomics Approach
作者： Fanny Schmidt , Monique van den Eijnden , Rosanna Pescini Gobert , Gabriela P. Saborio , Susanna Carboni
DOI: 10.1371/JOURNAL.PONE.0040457
关键词:
摘要: Multiple sclerosis (MS) is a neuroinflammatory disease characterized by progressive loss of myelin and failure oligodendrocyte (OL)-mediated remyelination, particularly in the phases disease. An improved understanding signaling mechanisms that control differentiation OL precursors may lead to identification new therapeutic targets for remyelination MS. About 100 mammalian Protein Tyrosine Phosphatases (PTPs) are known, many which involved both health We have undertaken systematic genomic approach evaluate PTP gene activity multiple autopsies related vivo vitro models This effort led Dusp15/VHY, previously believed be expressed only testis, as being transcriptionally regulated during MS lesions. Subsequent RNA interference studies revealed Dusp15/VHY key regulator differentiation. Finally, we identified PDGFR-beta SNX6 novel specific Dusp15 substrates, providing an indication how this might exert over
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