Reactive Oxygen Metabolite Production is Inhibited by Histamine and H 1 -antagonist Dithiaden in Human PMN Leukocytes
作者： Katarína Drábiková , Rado Nosál' , Viera Jančinová , Milan Číž , Antonín Lojek
DOI: 10.1080/1071576021000006590
关键词:
摘要: The study evaluated the distinction between extracellular and intracellular production of reactive oxygen metabolites (ROM) in isolated polymorphonuclear leukocytes (PMNL) stimulated with opsonised zymosan (OZ) investigated its modulation by endogenous mediator histamine (0.1-100 w mol/l) H 1 -antagonist dithiaden (1-100 mol/l). For this observation, a modified luminol an isoluminol amplified chemiluminescence (CL) technique were used. Our results showed that PMNL activated OZ responded respiratory burst accompanied both extra- generation ROM. Histamine significantly decreased component chemilumiescence OZ. While part CL same potency, preferentially CL. fact as well indicates tha...
informahealthcare.com
researchgate.net 参考文章(33)
Ulf-Henrik Mellqvist, Markus Hansson, Mats Brune, Claes Dahlgren, Svante Hermodsson, Kristoffer Hellstrand, Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine Blood. ,vol. 96, pp. 1961- 1968 ,(2000) , 10.1182/BLOOD.V96.5.1961
Inbal HAZAN, Raya DANA, Yoseph GRANOT, Rachel LEVY, Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan. Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidase. Biochemical Journal. ,vol. 326, pp. 867- 876 ,(1997) , 10.1042/BJ3260867
John I. Gallin, Ralph Snyderman, Ira M. Goldstein, Inflammation: Basic principles and clinical correlates ,(1988)
Robert C. Allen, [36] Phagocytic leukocyte oxygenation activities and chemiluminescence: A kinetic approach to analysis Methods in Enzymology. ,vol. 133, pp. 449- 493 ,(1986) , 10.1016/0076-6879(86)33085-4
G Briheim, O Stendahl, C Dahlgren, Intra- and extracellular events in luminol-dependent chemiluminescence of polymorphonuclear leukocytes. Infection and Immunity. ,vol. 45, pp. 1- 5 ,(1984) , 10.1128/IAI.45.1.1-5.1984
C Dahlgren, K Hellstrand, S Hermodsson, A Asea, Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites Journal of Immunology. ,vol. 153, pp. 4940- 4947 ,(1994)
T. -L. Ching, J. G. Koelemij, A. Bast, The effect of histamine on the oxidative burst of HL60 cells before and after exposure to reactive oxygen species. Inflammation Research. ,vol. 44, pp. 99- 104 ,(1995) , 10.1007/BF01782018
F. M. Baroody, R. M. Naclerio, Antiallergic effects of H1-receptor antagonists. Allergy. ,vol. 55, pp. 17- 27 ,(2000) , 10.1034/J.1398-9995.2000.00803.X
A. Lojek, J. Ĉerný, P. Němec, J. Niĉovský, V. Soška, M. Ĉíž, H. Slavíková, L. Kubala, Phagocyte‐induced oxidative stress in patients with haemodialysis treatment and organ transplantation Biofactors. ,vol. 8, pp. 165- 168 ,(1998) , 10.1002/BIOF.5520080128
Shigenobu Umeki, Effects of anti-allergic drugs on human neutrophil superoxide-generating NADPH oxidase Biochemical Pharmacology. ,vol. 43, pp. 1109- 1117 ,(1992) , 10.1016/0006-2952(92)90619-T