Biochemical and immunohistochemical correlates of kindling-induced epilepsy: role of calcium binding protein.
作者： J.J. Miller , K.G. Baimbridge
DOI: 10.1016/0006-8993(83)90264-0
关键词:
摘要: The levels and distribution of calcium binding protein (CaBP) were examined in the central nervous system rats exhibiting kindling-induced epilepsy. Following commissural kindling, concentration CaBP hippocampal formation was significantly reduced but no change observed total soluble or calmodulin, another calcium-related protein. Histochemical examination kindled animals revealed a localized depletion CaBP-like immunoreactivity restricted to dentate granule cell-mossy fiber formation. These data demonstrate correlation between loss from cells epilepsy, underlying mechanism which may involve an impairment regulate their intracellular environment when challenged with high frequency electrical stimulation.
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