Genetic Methods of Polymer Synthesis

摘要: Genetic methods of polymer synthesis have become an increasingly prominent strategy for the well-controlled architectures. The exact control molecular weight and sequence protein biosynthesis permits production protein-based polymers in which functional group placement can be controlled on angstrom length scale hierarchical assembly affords structural macroscopic scale. Protein polymers, produced via engineering strategies, captured many sequence, structural, properties naturally occurring proteins such as silk, collagen, elastin. Artificial with sequences designed de novo also been shown to form lamellar crystalline structures, liquid phases, reversible hydrogels. incorporation nonnatural amino acids into has further expanded their chemical versatility; appropriate expression host alkenes, alkynes, azides, ketones, aryl halides, other groups. strategies permit research commercial applications including drug delivery, vascular graft engineering, tissue high performance materials. Keywords: protein polymers; polymer synthesis; protein engineering; genetic engineering; fibrous proteins; artificial proteins; nonnatural