Magnetic Resonance Imaging Quantitation of Changes in Muscle Volume During 7 Days of Strict Bed Rest

摘要: FERRANDO AA, STUART CA, BRUNDER DG, HILLMAN GR. Magnetic resonance imaging quantitation of changes in muscle volume during 7 days strict bed rest. Aviat Space Environ Med 1995; 66:976-81. Background: Prolonged rest results a loss leg lean body mass. Previous studies using as model for microgravity have shown decreases mass after 12 and 14 d, 5 17 wk. Hypothesis: As magnetic (MRI) can provide precise non-invasive means determining volume, we sought to determine if could be detected periods short d. Methods: Five young, healthy, male volunteers were subjected d absolute Each subject underwent MRI segmental volumes the calves thighs before Eleven (calf) nine (thigh) contiguous 1-cm thick transaxial images generated over prescribed regions Technicare imager with 0.6T superconducting magnet coil. Image processing was performed generalized 8-bit medical image analysis package developed at University Texas Medical Branch. Images analyzed non-muscle (including fat, blood vessel, bone marrow volumes). Results: The demonstrated rest-induced significant thigh (3.0%, p < 0.05) volume. Conclusions: We conclude that computerized provides sensitive tool capable detecting little 3.0% 7-d period