Antimalarial Activity of Cassane- and Norcassane-Type Diterpenes from Caesalpinia crista and Their Structure–Activity Relationship
作者： Surya Kant Kalauni , Suresh Awale , Yasuhiro Tezuka , Arjun Hari Banskota , Thein Zaw Linn
DOI: 10.1248/BPB.29.1050
关键词:
摘要: Malaria is one of the most life-threatening infectious diseases worldwide and claims millions peoples life each year. The appearance drug-resistance Plasmodium falciparum has made treatment malaria increasingly problematic, thus, it a dire need to search new alternatives current drugs. In present study, 44 cassane- norcassane-type diterpenes isolated from Caesalpinia crista Myanmar Indonesia were evaluated for their antimalarial activity against parasite FCR-3/A2 clone in vitro. Most tested displayed activity, norcaesalpinin E (28) showed potent with an IC50 value 0.090 μM, more than clinically used drug chloroquine (IC50, 0.29 μM). Based on observed results, structure–activity relationship been established.
core.ac.uk
sci-hub.se 参考文章(11)
W Trager, J. Jensen, Human malaria parasites in continuous culture Science. ,vol. 193, pp. 673- 675 ,(1976) , 10.1126/SCIENCE.781840
Nobutoshi Murakami, Masanori Sugimoto, Motoyuki Kawanishi, Satoru Tamura, Hye-Sook Kim, Khurshida Begum, Yusuke Wataya, Motomasa Kobayashi, New semisynthetic quassinoids with in vivo antimalarial activity. Journal of Medicinal Chemistry. ,vol. 46, pp. 638- 641 ,(2003) , 10.1021/JM0201971
Arjun H. Banskota, Faisal Attamimi, Tepy Usia, Thein Zaw Linn, Yasuhiro Tezuka, Surya K. Kalauni, Shigetoshi Kadota, Novel norcassane-type diterpene from the seed kernels of Caesalpinia crista Tetrahedron Letters. ,vol. 44, pp. 6879- 6882 ,(2003) , 10.1016/S0040-4039(03)01722-2
Ariati S Budimulja, Syafruddin, Pramuan Tapchaisri, Prapon Wilairat, Sangkot Marzuki, The sensitivity of Plasmodium protein synthesis to prokaryotic ribosomal inhibitors Molecular and Biochemical Parasitology. ,vol. 84, pp. 137- 141 ,(1997) , 10.1016/S0166-6851(96)02781-8
Surya K. Kalauni, Suresh Awale, Yasuhiro Tezuka, Arjun H. Banskota, Thein Zaw Linn, Shigetoshi Kadota, Cassane- and Norcassane-Type Diterpenes of Caesalpinia crista from Myanmar Journal of Natural Products. ,vol. 67, pp. 1859- 1863 ,(2004) , 10.1021/NP049742M
Thein Zaw Linn, Suresh Awale, Yasuhiro Tezuka, Arjun H. Banskota, Surya K. Kalauni, Faisal Attamimi, Jun-ya Ueda, Puji Budi Setia Asih, Din Syafruddin, Ken Tanaka, Shigetoshi Kadota, Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum. Journal of Natural Products. ,vol. 68, pp. 706- 710 ,(2005) , 10.1021/NP0401720
Suresh Awale, Thein Zaw Linn, Yasuhiro Tezuka, Surya Kant Kalauni, Arjun Hari Banskota, Faisal Attamimi, Jun-ya Ueda, Shigetoshi Kadota, Constituents of Caesalpinia crista from Indonesia Chemical & Pharmaceutical Bulletin. ,vol. 54, pp. 213- 218 ,(2006) , 10.1248/CPB.54.213
D. Klayman, Qinghaosu (artemisinin): an antimalarial drug from China Science. ,vol. 228, pp. 1049- 1055 ,(1985) , 10.1126/SCIENCE.3887571
Surya Kant Kalauni, Suresh Awale, Yasuhiro Tezuka, Arjun Hari Banskota, Thein Zaw Linn, Shigetoshi Kadota, Methyl Migrated Cassane-Type Furanoditerpenes of Caesalpinia crista from Myanmar Chemical & Pharmaceutical Bulletin. ,vol. 53, pp. 1300- 1304 ,(2005) , 10.1248/CPB.53.1300
Surya Kant Kalauni, Suresh Awale, Yasuhiro Tezuka, Arjun Hari Banskota, Thein Zaw Linn, Shigetoshi Kadota, New cassane-type diterpenes of Caesalpinia crista from Myanmar. Chemical & Pharmaceutical Bulletin. ,vol. 53, pp. 214- 218 ,(2005) , 10.1248/CPB.53.214