Serum omega-3 and omega-6 fatty acid concentrations and natural fertility.

摘要: STUDY QUESTION Are serum omega-3 and omega-6 essential fatty acid concentrations associated with the probability of conceiving? SUMMARY ANSWER There is no strong association between acids conceiving naturally. WHAT IS KNOWN ALREADY Omega-3 have been shown to play an important role in reproduction animal models, while conflicting results reported human studies infertile women. It unknown what extent omega impact natural fertility. DESIGN, SIZE, DURATION A nested, case-control study was conducted consisting 200 participants [fertile: conceived within 3 cycles attempt (n = 50), subfertile: 4 12 cycles (n = 100) infertile: did not conceive (n = 50)] randomly selected from Time Conceive cohort, a prospective time-to-pregnancy (2008 2015). PARTICIPANTS/MATERIALS, SETTING, METHODS In study, women aged 30-44 years who were trying for <3 months had history infertility recruited followed until end their pregnancy or ~1 year attempt. For this collected early woman's analysed anti-Mullerian hormone (AMH) by liquid chromatography-mass spectrometry. The primary outcome positive home test. secondary outcomes miscarriage AMH level. discrete-time Cox proportional hazards model used estimate fecundability ratio. odds ratios calculated using logistic regression. level (natural log transformed) Pearson's Correlation. MAIN RESULTS AND THE ROLE OF CHANCE total provided 1321 cycles analysis.Mean omega-3, omega-6:omega-3 significantly differ fertile, subfertile groups. associations (all ~1.0) individual concentrations, including alpha-linolenic acid, eicosapentaenoic docosahexaenoic acids, linoleic (LA), dihommo-gamma linolenic arachidonic acid. significant any concentration age-adjusted miscarriage. No found AMH. LIMITATIONS, REASONS FOR CAUTION This limited sample size. derived at single timepoint first cycle enrollment. Serum may therefore be representative all critical timepoints menstrual throughout attempts conceive. Additionally, enrolled 30 years age older, findings apply younger WIDER IMPLICATIONS FINDINGS These data would suggest that levels are fertility risk However, due above-mentioned limitations, future investigation still needed determine whether supplementation benefit planning FUNDING/COMPETING INTEREST(S) supported Division Reproductive Endocrinology Infertility University North Carolina Chapel Hill, NIH/NICHD (R21 HD060229-01 R01 HD067683-01) and, part, Intramural Research Program National Institute Environmental Health Sciences (Z01ES103333). Dr. Jukic received vitamin D supplements research Theralogix, Inc. authors other conflicts interest disclose. TRIAL REGISTRATION NUMBER N/A.