How Often Do BRCA Mutation Carriers Tell Their Young Children of the Family's Risk for Cancer? A Study of Parental Disclosure of BRCA Mutations to Minors and Young Adults

摘要: Purpose Predictive genetic testing for adult-onset diseases is generally discouraged until the age at which interventions are believed to be helpful. Yet, many BRCA mutation carriers discuss their results with children. This study describes prevalence and experiences of parental communication children under 25 years old. Patients Methods Forty-two completed semistructured telephone interviews assessing self-reported disclosure offspring parent disclosure. Qualitative responses were coded themes. χ2 tests logistic regression analyses robust variance estimates used evaluate child characteristics associated Results Fifty-five percent parents reported discussing hereditary risk cancer least one child. By report, 49% 86 learned test or risk. Offspring was strongly wi...