Bipolar Bozukluk ve Diyabetes Mellitus Bipolar Disorder and Diabetes Mellitus

摘要: Comorbid endocrine and cardiovascular situations with bipolar disorder usually result from the itself or as a consequence of its treatment. With habits lifestyle, genetic tendency side effects, this situation is becoming more striking. Subpopulations disorders patients should be considered at high risk for diabetes mellitus. The prevalence mellitus in may three times greater than general population. Comorbidity causes pathophysiological overlapping neurobiological webs cases. Signal mechanisms glycocorticoid/insulin immunoinflammatory effector systems are junction points that point out pathophysiology between medical cases susceptible to stress. Glycogen synthetase kinase (GSK-3) serine/treonine inhibits transport glucose stimulated by insulin. It affected diabetes, cancer, inflammation, Alzheimer disease disorder. Hypoglycemic effect lithium occurs via inhibiting glycogen kinase. When comorbid other -for example disorder, especially during acute manic episodes-,