Individual data pooled analyses to improve understanding of adjuvant therapy in colon cancer: Review of the ACCENT collaborative group

摘要: The Adjuvant Colon Cancer Endpoints (ACCENT) Group is an international, collaborative, individual-patient data analysis now including 20,898 patients enrolled in 18 adjuvant therapy trials for resected stage II and III colon cancer, spanning the years 1977 to 1999. This article discusses proceedings published presented since inception of ACCENT 2003, which notably include evaluation 3-year disease-free survival as acceptable end point studies, particularly improved understanding time-dependent patterns failure benefit therapy.