Promising Anti-sickling and Fetal Hemoglobin Inducing Effects of Boerhavia diffusa Root Extract on Sickle Cell Erythrocytes
作者： Firdosh Shah , Mitesh Dwivedi , Chirag V. Parikh
DOI: 10.1016/J.HERMED.2020.100398
关键词:
摘要: Abstract Sickle cell disease (SCD) is a genetic blood disorder and currently available drugs are ineffective come with numerous side effects B. diffusa has been reported as an important herb in the ayurvedic texts. Although studies have shown immunomodulatory anti-inflammation activities, anti-sickling activity fetal hemoglobin (HbF) inducing potential of Boerhavia not yet explored. Therefore, present study was aimed to assess HbF induction aqueous root extract sickle erythrocytes obtained from SCD patients. The vitro evaluated microscopically via Emmel Test. determined on through HPLC. different doses time-dependent treatments test drug control (hydroxyurea) suggested that 30 mg/mL for 60 min exerts significant effect compared negative (P
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